Home > トピックス・イベント > ｢修飾シグナル病」第2回国際シンポジウム
文部科学省・科学研究費補助金・新学術領域研究
｢修飾シグナル病」第2回国際シンポジウム
開催概要
| 名称 | 文部科学省・科学研究費補助金・新学術領域研究 ｢修飾シグナル病」第2回国際シンポジウム 2nd International Symposium on Protein Modifications in Pathogenic Dysregulation of Signaling |
|---|---|
| 会期 | 平成27年1月23日（金）、24日（土） |
| 会場 | 東京大学医科学研究所1号館1F講堂 〒108-8639 東京都港区白金台 4-6-1[キャンパスマップ・交通案内] |
| 参加費 | 無料 |
| 参加申込み | 参加登録1月16日（金）正午締切 ※下記のフォームからご登録をお願いします。 ※事前申し込みがなくても参加可能ですが、参加者数を把握するためできるだけ登録をお願いたします。 |
| ポスター |  PDF (1.5MB) |
| お問い合せ | 東京大学医科学研究所 分子発癌分野 〒108-8639 東京都港区白金台4-6-1 TEL: 03-5449-5275 FAX: 03-5449-5421 E-mail: symposium@shushoku-signal.com |
参加登録
プログラム
January 23 (Fri)
| Opening remarks | ||
|---|---|---|
| 9:30-9:35 | Jun-ichiro Inoue | |
| Session 1. | Post-translational modifications in the regulation of NF-κB and related signaling I （Chairs: Jun-ichiro Inoue & Kazuhisa Ichikawa） |
|
| 9:35-10:00 | Jun-ichiro Inoue | “The role of ubiquitin ligase TRAF6 in osteoclastogenesis” |
| 10:00-10:50 | Seok Hee Park (Sungkyunkwan University, Korea) | Special Lecture 1 “Distinct Roles of A20 ubiquitin editing enzyme in TGF-β signaling pathway” |
Coffee Break (20 min) |
||
| Session 2. | Post-translational modifications in the regulation of NF-κB and related signaling II （Chairs: Fuminori Tokunaga & Mutsuhiro Takekawa） |
|
| 11:10-11:35 | Fuminori Tokunaga | “Linear ubiquitination-mediated NF-κB regulation” |
| 11:35-12:25 | Shao-Cong Sun (University of Texas, MD Anderson Cancer Center, USA) |
Special Lecture 2 “Regulation of noncanonical NF-kB signaling by ubiquitination” |
Lunch (65 min) |
||
| Session 3. | Analysis of cellular signaling by structural biology （Chairs: Ryuichiro Ishitani & Masaaki Oyama） |
|
| 13:30-13:55 | Ryuichiro Ishitani | ”Structural basis for catalytic mechanisim of DncV, bacterial homologue of cyclic GMP-AMP synthase” |
| 13:55-14:15 | Masaki Mishima | “Structural insights into the recruitment of SMRT by the co-repressor SHARP under phosphorylative regulation” |
| 14:15-14:35 | Yusuke Sato | “Structural basis for specific cleavage of M1- and K63-linked polyubiquitin chains by the CYLD deubiquitinase” |
Coffee break (20 min) |
||
| Session 4. | Regulation of cellular functions by post-translational modifications （Chairs: Masahide Takahashi & Hirofumi Kai) |
|
| 14:55-15:15 | Takeshi Endo | “Signal transduction mechanisms regulating myofibrillogenesis and alveolarization” |
| 15:15-15:35 | Tomotake Kanki | “The signaling pathway regulating mitochondria autophagy” |
| 15:35-15:55 | Tatsuya Saitoh | “Regulation of innate immune response by post-translational modifications” |
Coffee break (20 min) |
||
| Session 5. | Mathematical simulation of signal transduction （Chairs: Kazuhisa Ichikawa & Hiroyuki Kubota） |
|
| 16:15-16:40 | Kazuhisa Ichikawa | “How is the oscillation of nuclear NF-κB regulated?” |
| 16:40-17:30 | Savas Tay (ETH Zürich, Switzerland) |
Special Lecture 3 “Noise facilitates NF-κB entrainment and transcriptional control under complex signalling inputs” |
| 17:30-17:50 | Hiroyuki Kubota | “Reconstruction of insulin signal flow from phosphoproteome and metabolome data” |
January 24 (Sat)
| Session 6. | Student and young scientist presentation （Chairs: Atsushi Enomoto & Taichiro Tomida） |
|
|---|---|---|
| 9:00-9:15 | Atsushi Uematsu | “Identification of a novel E3 ligase for deubiquitination enzyme CYLD.” |
| 9:15-9:30 | Kentaro Kajiwara | “Spatiotemporal regulation of Src in epithelial morphogenesis” |
| Session 7. | Dysregulation of post-translational modifications in human diseases （Chairs: Jun-ichiro Inoue & Fuminori Tokunaga） |
|
| 9:30-9:55 | Shoji Yamaoka | “A20 interacts with Caspase-8 and FADD to protect adult T-cell leukemia cells” |
| 9:55-10:15 | Hirofumi Kai | “Podocyte-p53 is essential to control the progression of hereditary renal disease Alport syndrome” |
| 10:15-10:35 | Akio Kihara | “Regulation of fatty aldehyde dehydrogenases by lipid modification” |
Coffee Break (20 min) |
||
| Session 8. | Post-translational modifications in the regulation of MAPK signaling （Chairs: Mutsuhiro Takekawa & Takeshi Endo） |
|
| 10:55-11:20 | Mutsuhiro Takekawa | “MCRIP1, a novel ERK substrate, mediates ERK-induced epigenetic gene silencing during epithelial-to-mesenchymal transition” |
| 11:20-12:10 | Bin Zheng (MGH, Harvard Medical School, USA) |
Special Lecture 4 “Crosstalk between BRAF-MEK-ERK and LKB1-AMPK Signaling pathways and its therapeutic implications “ |
| 12:10-12:30 | Kazuhiro Aoki | “Quantitative analysis of ERK signaling with live cell imaging” |
Lunch（70 min） |
||
| Session 9. | Regulation of AKT signaling during cell fate decisions （Chairs: Masahide Takahashi & Yuji Yamanashi） |
|
| 13:40-14:05 | Masahide Takahashi | “Akt/girdin signaling in cancer progression” |
| 14:05-14:55 | John Blenis (Weill Cornell Medical College, USA) |
Special Lecture 5 “mTORC1 targets, metabolism and cancer.” |
| 14:55-15:15 | Junko Sasaki | “The novel mechanism of tumor suppression by INPP4B” |
Coffee Break (20 min) |
||
| Session 10. | Proteomics approaches to elucidate signal transduction networks （Chairs: Masaaki Oyama & Tatsuya Sawasaki） |
|
| 15:35-16:00 | Masaaki Oyama | “High-resolution phosphoproteomics defines regulation of cancer cell signaling” |
| 16:00-16:20 | Kazuo Yamamoto | “A novel method to identify O-GlcNAcylated proteins using a soluble N-acetylgalactosaminyltransferase |
| 16:20-16:40 | Tatsuya Sawasaki | “Polyubiquitin-chain interactome by cell-free human protein array” |
| Closing Remarks | ||
| 16:40-16:45 | Mutsuhiro Takekawa | |
キャンパスマップ・交通案内
| Ａ | 東京メトロ南北線・都営地下鉄三田線白金台駅下車。 |
| Ｂ | JR山手線目黒駅東口から徒歩15分。 JR山手線目黒駅東口から都バス品93大井競馬場行で、白金台駅前下車。あるいは、都バス黒77千駄ヶ谷行または橋86新橋駅行で、 東大医科研病院西門下車。 |
| Ｃ | JR品川駅から都バス品93目黒駅行で、白金台駅前下車。 |
| Ｄ | 東京メトロ日比谷線広尾駅そばの都バス広尾橋から黒77または橋86目黒駅行で、 東大医科研病院西門下車。 |
