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2015.9.25 市川一寿（東京大・医科研）武川睦寛（東京大・医科研）
Ohshima D, Arimoto-Matsuzaki K, Tomida T, Takekawa M and Ichikawa K.
Spatio-temporal dynamics and mechanisms of stress-granule assembly.
PLoS Comput. Biol. 11: e1004326 doi: 10.1371/journal.pcbi.1004326 (2015) [URL][PubMed]
2015.9.25 冨田太一郎、武川睦寛（東京大・医科研）
Tomida T, Takekawa M and Saito H.
Oscillation of p38 activity controls efficient pro-inflammatory gene expression.
Nature Commun. 6: 8350 doi:10.1038/ncomms9350 (2015) [URL][PubMed]
2015.9.25 齊藤愛記、山岡昇司（東京医科歯科大・院医歯学総合・ウイルス制御学）
Kinpara S, Ito S, Takahata T, Saitoh Y, Hasegawa A, Kijiyama M, Utsunomiya A, Masuda M, Miyazaki Y, Matsuoka M, Nakamura M, Yamaoka S, Masuda T, Kannagi M.
Involvement of double-stranded RNA-dependent protein kinase and antisense viral RNA in the constitutive NFκB activation in adult T-cell leukemia/lymphoma cells.
Leukemia. 2015 Jun;29(6):1425-9. doi: 10.1038/leu.2015.1.[PubMed]
2015.9.25 山岡昇司（東京医科歯科大・院医歯学総合・ウイルス制御学）
Hori T, Barnor J, Huu TN, Morinaga O, Hamano A, Ndzinu J, Frimpong A, Minta-Asare K, Amoa-Bosompem M, Brandful J, Odoom J, Bonney J, Tuffour I, Owusu BA, Ofosuhene M, Atchoglo P, Sakyiamah M, Adegle R, Appiah-Opong R, Ampofo W, Koram K, Nyarko A, Okine L, Edoh D, Appiah A, Uto T, Yoshinaka Y, Uota S, Shoyama Y, Yamaoka S.
Procyanidin trimer C1 derived from Theobroma cacao reactivates latent human immunodeficiency virus type 1 provirus.
Biochem Biophys Res Commun. 2015 Apr 3;459(2):288-93. doi: 10.1016/j.bbrc.2015.02.102.[PubMed]
2015.9.25 山岡昇司、齊藤愛記（東京医科歯科大・院医歯学総合・ウイルス制御学）
Yasunori Saitoh, Akiko Hamano, Kanako Mochida, Ayaka Kakeya, Masaya Uno, Eri Tsuruyama, Hirona Ichikawa, Fuminori Tokunaga, Atae Utsunomiya, Toshiki Watanabe and Shoji Yamaoka
A20 targets caspase-8 and FADD to protect HTLV-I infected cells.
Leukemia, in press. [PubMed]
2015.7.2 越川直彦（神奈川県立がんセンター臨床研究所・がん生物学部）
Naohiko Koshikawa, Daisuke HOSHINO, Hiroaki TANIGUCHI, Tomoko MINEGISHI, Taizo Tomari, Sung-Ouk Nam, Mitsuko Aoki, Takayuki Sueta, Takashi Nakagawa, Shingo Miyamoto, Kazuki Nabeshima, Alissa M Weaver, and Motoharu Seiki
Proteolysis of EphA2 converts it from a tumor suppressor to an oncoprotein
Cancer Res. 2798.2014. [PubMed] [URL]
2015.4.2 神吉智丈（新潟大・院医歯学総合・機能制御学）
Hirota Y, Yamashita SI, Kurihara Y, Jin X, Aihara M, Saigusa T, Kang D, Kanki T.
Mitophagy is primarily due to alternative autophagy and requires the MAPK1 and MAPK14 signaling pathways.
Autophagy. 2015 11(2):332-343. [PubMed]
2015.3.27 遠藤　剛（千葉大学 大学院理学研究科 生物学教室）
Endo, T.
Molecular mechanisms of skeletal muscle development, regeneration, and osteogenic conversion.
Bone (2015) in press (doi: 10.1016/j.bone.2015.02.028) [PubMed]
2015.3.27 遠藤　剛（千葉大学 大学院理学研究科 生物学教室）
遠藤　剛，渡邊-高野晴子，高野和儀
【総説】DA-Rafの癌抑制機能と肺胞形成における役割．
The Lung Perspectives　特集「肺癌Up-To-Date」，メディカルレビュー社．Vol. 23, No. 1, pp. 70–75 (2015). [URL]
2015.3.27 佐藤裕介（東大・構造生物）
Aya Toma, Tomio S. Takahashi, Yusuke Sato, Atsushi Yamagata, Sakurako Goto-Ito, Shinichiro Nakada, Atsuhiko Fukuto, Yasunori Horikoshi, Satoshi Tashiro, Shuya Fukai
Structural Basis for Ubiquitin Recognition by Ubiquitin-Binding Zinc Finger of FAAP20
PLOS ONE 2015 DOI: 10.1371/journal.pone.0120887 [URL] [PubMed]
2015.3.4 武川睦寛（東京大・医科研）
Ichikawa K, Kubota Y, Nakamura T, Weng JS, Tomida T, Saito H and Takekawa M.
MCRIP1, an ERK substrate, mediates ERK-induced gene silencing during epithelial-mesenchymal transition by regulating the co-repressor CtBP.
Molecular Cell (2015) [URL] [PubMed]
2015.2.20 井上純一郎（東京大・医科研）
Gohda, J., Ma, Y., Huang, Y., Zhang, Y., Gu, L., Han, Y., Li, T., Gao, G.F., Inoue, J., Iwamoto, A. and Ishida, T. HIV-1 replicates in human osteoclasts and enhances their differentiation in vitro. Retrovirology (2015). In press [URL] [PubMed]
2015.2.20 井上純一郎（東京大・医科研）
Ito-Kureha, T., Koshikawa, N., Yamamoto, M., Semba, K., Yamaguchi, N., Yamamoto, T., Seiki, M. and Inoue, J. Tropomodulin 1 expression driven by NF-κB enhances breast cancer growth. Cancer Res. 75, 62–72 (2015). [PubMed]
2015.2.20 井上純一郎（東京大・医科研）
Blackburn, J., Kawasaki, K., Porntaveetus, T., Kawasaki, M., Otsuka-Tanaka, Y., Miake, Y., Ota, M.S., Watanabe, M., Hishinuma, M., Nomoto, T., Oommen, S., Ghafoor, S., Harada, F., Nozawa-Inoue, K., Maeda, T., Peterková, R., Lesot, H., Inoue, J., Akiyama, T., Schmidt-Ullrich, R., Liu, B., Hu, Y., Page, A., Ramírez, A., Sharpe, P.T. and Ohazama, A. Excess NF-κB induces ectopic odontogenesis in embryonic incisor epithelium. J. Dent. Res. 94, 121-128 (2015). [PubMed]
2015.2.20 井上純一郎（東京大・医科研）
Akiyama, N., Shinzawa, M., Miyauchi, M., Yanai, H., Tateishi, R., Shimo, Y., Ohshima, D., Matsuo, M., Sasaki. I., Hoshino, K., Wu, G., Yagi, S., Inoue, J., Kaisho, T. and Akiyama, T. Limitation of immune tolerance-inducing thymic epithelial cell development by Spi-B-mediated negative feedback regulation. J. Exp. Med. 211, 2425-2438 (2014). [PubMed]
2015.2.20 井上純一郎（東京大・医科研）
Akiyama, T., Qin Inoue, J. Identification of transcription factors activated in thymic epithelial cells during embryonic thymus development. Methods Mol. Biol. 1164, 163-170 (2014). [PubMed]
2015.2.3
論文内容		 佐藤裕介（東大・構造生物）
Yusuke Sato, Eiji Goto, Yuri Shibata, Yuji Kubota, Atsushi Yamagata, Sakurako Goto-Ito, Keiko Kubota, Jun-ichiro Inoue, Mutsuhiro Takekawa, Fuminori Tokunaga and Shuya Fukai
Structures of CYLD USP with Met1- or Lys63-linked diubiquitin reveal mechanisms for dual specificity.
Nat. Struct. Mol. Biol. (2015) doi:10.1038/nsmb.2970 [URL] [PubMed]
2015.1.22 神吉智丈（新潟大・院医歯学総合・バイオシグナリング研究室）
Kanki T, Furukawa K, Yamashita SI.
Mitophagy in yeast: Molecular mechanisms and physiological role.
Biochim Biophys Acta. (2015) (doi: 10.1016/j.bbamcr.2015.01.005.) [PubMed]
2015.1.22 神吉智丈（新潟大・院医歯学総合・バイオシグナリング研究室）
Kanki T, Okamoto K.
Assays for autophagy II: Mitochondrial autophagy.
Methods Mol Biol. 1163,165-173.(2014) [PubMed]
2014.12.25 山本一夫（東京大学大学院新領域創成科学研究科）
Takeda, K., Qin, S., Matsumoto, N., Yamamoto, K.:
Association of malectin with ribophorin I is crucial for attenuation of misfolded glycoprotein secretion.
Biochem. Biophys. Res. Commun. 454, 436-440 (2014). [PubMed]
2014.12.25 山本一夫（東京大学大学院新領域創成科学研究科）
出前講義　県立浦和高等学校にて「糖鎖生物学への招待」（11月26日）
2014.12.24 野村真樹（京都大学iPS細胞研究所）
中村正裕・野村真樹・溝曽路祥孝・吉田善紀・渡辺　亮
幹細胞・発生研究におけるシングルセル遺伝子発現解析
実験医学 (2015), Vol. 33, No.1 Page 15-19 .[URL]
2014.11.10 高橋雅英（名大・院医・分子病理）
Nakai T, Nagai T, Tanaka M, Itoh N, Asai N, Enomoto A, Asai M, Yamada S, Saifullah AB, Sokabe M, Takahashi M, Yamada, K.
Girdin phosphorylation is crucial for synaptic plasticity and memory: Potential role in the interaction of BDNF/TrkB/Akt signaling with NMDA receptor.
J Neurosci. 34: 14995-15008 (2014).[URL] [PubMed]
2014.11.5
論文内容
山梨裕司（東大・医科研・腫瘍抑制）
Tohru Tezuka, Akane Inoue, Taisuke Hoshi, Scott D. Weatherbee, Robert W. Burgess, Ryo Ueta, Yuji Yamanashi
The MuSK activator agrin has a separate role essential for postnatal maintenance of neuromuscular synapses
Proc. Natl. Acad. Sci. USA. (2014) (doi:10.1073/pnas.1408409111)[URL] [PubMed]
2014.9.24
論文内容
山梨裕司（東大・医科研・腫瘍抑制）
Sumimasa Arimura, Takashi Okada, Tohru Tezuka, Tomoko Chiyo, Yuko Kasahara, Toshiro Yoshimura, Masakatsu Motomura, Nobuaki Yoshida, David Beeson, Shin’ichi Takeda, Yuji Yamanashi
DOK7 gene therapy benefits mouse models of diseases characterized by defects in the neuromuscular junction
Science 345: 1505-1508, 2014 [解説] [URL] [PubMed]
新聞報道：朝日新聞 朝刊 9月19日、Science誌News記事
2014.9.12
 市川一寿（東京大・医科研）
Ohshima, D. and Ichikawa, K.
Regulation of nuclear NF-κB oscillation by a diffusion coefficient and its biological implications
PLoS ONE [URL][PubMed]
2014.8.29
論文内容 		石谷　太（九州大学・生体防御医学研究所）
Shimizu N, Ishitani S, Sato A, Shibuya H, *Ishitani T
Hipk2 and PP1c cooperate to maintain Dvl protein levels required for Wnt signal transduction.
Cell Reports, 2014 [URL] [PubMed]
2014.8.29
 石谷　太（九州大学・生体防御医学研究所）
Delgado ER, Yang J, So J, Leimgruber S, Kahn M, Ishitani T, Shin D, Mustata Wilson G, *Monga SP.
Identification and characterization of a novel small-molecule inhibitor of β-catenin signaling.
The American Journal of Pathology, 2014 [URL] [PubMed]
2014.7.29
論文内容 		高橋雅英（名大・院医・分子病理）
Weng, L., Enomoto, A., Miyoshi, H., Takahashi, K., Asai, N., Morone, N., Jiang, P., An, J., Kato, T., Kuroda, K., Watanabe, T., Asai, M., Ishida-Takagishi, M., Murakumo, Y., Nakashima, H., Kaibuchi, K. and Takahashi, M.
Regulation of cargo-selective endocytosis by dynamin 2 GTPase-activating protein girdin.
EMBO J. 2014 Jul 24. pii: e201488289. [Epub ahead of print] [PubMed]
報道発表：中日新聞　7月25日朝刊
2014.7.29 久保田浩行（九州大学・生医研）
Katsuyuki Yugi†, Hiroyuki Kubota†, Yu Toyoshima, Rei Noguchi, Kentaro Kawata,Yasunori Komori, Shinsuke Uda, Katsuyuki Kunida, Yoko Tomizawa, Yosuke Funato, Hiroaki Miki, Masaki Matsumoto, Keiichi I. Nakayama, Kasumi Kashikura, Keiko Endo, Kazutaka Ikeda,Tomoyoshi Soga and Shinya Kuroda (†: equal contribution)
Reconstruction of insulin signal flow from phosphoproteome and metabolome data
Cell reports. (2014) [URL][PubMed]
2014.5.23 高橋雅英（名大・院医・分子病理）
Kato, T., Enomoto, A., Watanabe, T., Haga, H., Ishida, S., Kondo, Y., Furukawa, K., Urano, T., Mii, S., Weng, L., Takagishi, M., Asai, M., Asai, N., Kaibuchi, K., Murakumo, Y. and Takahashi, M.
TRIM27/MTRF-B-dependent integrin beta1 expression defines leading cells in cancer cell collecitives.
Cell Rep. 7: 1156–1167 (2014) [PubMed] [プレスリリース]
報道発表　朝日新聞、読売新聞、日本経済新聞、中日新聞　5月2日朝刊
2014.5.23 高橋雅英（名大・院医・分子病理）
Miyachi, H., Mii, S., Enomoto, A., Murakumo, Y., Kato, T., Asai, N., Komori, K. and Takahashi, M.
Role of Girdin in intimal hyperplasia in vein grafts and efficacy of atelocollagen-mediated application of siRNA for vein failure.
J. Vasc. Surg. in press (2014) doi: 10.1016/j.jvs.2013.06.080 [PubMed]
2014.5.23 高橋雅英（名大・院医・分子病理）
Ota, H., Hikita, T., Nishioka, T., Matsumoto, M., Ito, J., Asai, N., Enomoto, A., Takahashi, M., Kaibuchi, K., Sobue, K. and Sawamoto, K.
Proteomic analysis of Girdin-interacting proteins in migrating new neurons in the postnatal mouse brain.
Biochem. Biophys. Res. Commun. 442(1-2):16-21 (2013) [PubMed]
2014.5.21 遠藤　剛（千葉大学 大学院理学研究科 生物学教室）
Watanabe-Takano, H., Takano, K., Sakamoto, A., Matsumoto, K., Tokuhisa, T., Endo, T.*, Hatano, M.*  (*co-corresponding authors)
DA-Raf-dependent inhibition of the Ras-ERK signaling pathway in type 2 alveolar epithelial cells controls alveolar formation.
Proc. Natl. Acad. Sci. USA (2014) (doi: 10.1073/pnas.1321574111)
[日本語解説] [URL] [PubMed]
2014.5.21 遠藤　剛（千葉大学 大学院理学研究科 生物学教室）
Yamamoto, D. L., Vitiello, C., Zhang, J., Gokhin, D. S., Castaldi, A., Coulis, G., Piaser, F., Filomena, M. C., Eggenhuizen, P. J., Kunderfranco, P., Camerini, S., Takano, K., Endo, T., Crescenzi, M., Luther, P., Lieber, R. L., Chen, J., Bang, M.-L.
The nebulin SH3 domain is dispensable for normal skeletal muscle structure but is required for effective active load bearing in mouse.
J. Cell Sci. 126 (23): 5477-5489 (2013)[URL] [PubMed]
2014.5.21 神吉智丈（新潟大・院医歯学総合・バイオシグナリング研究室）
Aihara M, Jin X, Kurihara Y, Yoshida Y, Matsushima Y, Oku M, Hirota Y, Saigusa T, Aoki Y, Uchiumi T, Yamamoto T, Sakai Y, Kang D, Kanki T.
The Tor and Sin3-Rpd3 complex regulate expression of the mitophagy receptor protein Atg32.
J Cell Sci. (in press) pii: jcs.153254. [PubMed]
2014.5.16 深田吉孝（東京大・院理・生科）
Naohiro Kon, Tomoko Yoshikawa, Sato Honma, Yoko Yamagata, Hikari Yoshitane, Kimiko Shimizu, Yasunori Sugiyama, Chihiro Hara, Isamu Kameshita, Kenichi Honma and Yoshitaka Fukada.
CaMKII is essential for cellular clock and coupling between morning and evening behavioral rhythms
Genes Dev., 28, 1101-1110 (2014) [日本語解説][URL][PubMed]
2014.4.22 深田吉孝（東京大・院理・生科）、田口恵子（東北大・加齢医学研究所・遺伝子発現制御）
Vanja Pekovic-Vaughan, Julie Gibbs, Hikari Yoshitane, Nan Yang, Dharshika Pathiranage, Baoqiang Guo, Aya Sagami, Keiko Taguchi, David Bechtold, Andrew Loudon, Masayuki Yamamoto, Jefferson Chan, Gijsbertus T.J. van der Horst, Yoshitaka Fukada and Qing-Jun Meng
The circadian clock regulates rhythmic activation of the NRF2/glutathione-mediated antioxidant defense pathway to modulate pulmonary fibrosis.
Genes Dev., 28, 548-560 (2014) [PubMed]
2014.4.22 深田吉孝（東京大・院理・生科）
Hikari Yoshitane*, Haruka Ozaki*, Hideki Terajima*, Ngoc-Hien Du, Yutaka Suzuki, Shigeki Shimba, Taihei Fujimori, Shumio Sugano, Toshihisa Takagi, Wataru Iwasaki# and Yoshitaka Fukada# (*equal contribution, #corresponding authors)
CLOCK-controlled polyphonic regulations of circadian rhythms through canonical and non-canonical E-boxes.
Mol. Cell. Biol. (34, 1776-1787 (2014) [PubMed]
2014.4.22 深田吉孝（東京大・院理・生科）
Nicole Gossan, Feng Zhang, Baoqiang Guo, Ding Jin, Hikari Yoshitane, Aiyu Yao, Nick Glossop, Yong Q Zhang, Yoshitaka Fukada, Qing-Jun Meng
The E3 ubiquitin ligase UBE3A is an integral component of the molecular circadian clock through regulating the BMAL1 transcription factor.
Nucl. Acids Res. 42, 5765-5775 (2014) [PubMed]
2014.4.22 深田吉孝（東京大・院理・生科）
平成26年度 文部科学大臣表彰 科学技術賞　受賞 [URL]
2014.4.21 井上純一郎（東京大・医科研）
Akiyama, T., Shiraishi, T., Qin, J., Konno, H., Akiyama, N., Shinzawa, M., Miyauchi, M., Takizawa, N., Yanai, H., Ohashi, H., Miyamoto-Sato, E., Yanagawa, H., Yong, W., Shou, W. and Inoue, J.
Mitochondria–nucleus shuttling FK506-binding protein 51 interacts with TRAF proteins and facilitates the RIG-I-like receptor-mediated expression of type I IFN.
PLoS One 9(5):e95992 (2014). [PubMed]
2014.4.1 齊藤達哉（大阪大学・微生物病研究所）
報道発表「自然免疫応答の制御における細胞内分解系の役割」
薬事日報、2014年3月24日

Ono C, Ninomiya A, Yamamoto S, Abe T, Wen X, Fukuhara T, Sasai M, Yamamoto M, Saitoh T, Satoh T, Kawai T, Ishii KJ, Akira S, Okamoto T, Matsuura Y.
Innate immune response induced by baculovirus attenuates transgene expression in mammalian cells.
J Virol. 2013, 88, 2157-2167.[URL] [PubMed]
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