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研究成果

2011.3.31
論文内容
徳永文稔(阪大・院医・医化学)
Fuminori Tokunaga, Tomoko Nakagawa, Masaki Nakahara, Yasushi Saeki, Masami Taniguchi, Shin-ichi Sakata, Keiji Tanaka, Hiroyasu Nakano & Kazuhiro Iwai
SHARPIN is a component of the NF-κB-activating linear ubiquitin chain assembly complex.
Nature 471, 633-636, (2011)[PubMed]

2011.3.31
論文内容
徳永文稔(阪大・院医・医化学)
Fumiyo Ikeda, Yonathan Lissanu Deribe, Sigrid S. Skånland, Benjamin Stieglitz, Caroline Grabbe, Mirita Franz-Wachtel, Sjoerd J. L. van Wijk, Panchali Goswami, Vanja Nagy, Janos Terzic, Fuminori Tokunaga, Ariadne Androulidaki, Tomoko Nakagawa, Manolis Pasparakis, Kazuhiro Iwai, John P. Sundberg, Liliana Schaefer, Katrin Rittinger, Boris Macek & Ivan Dikic
SHARPIN forms a linear ubiquitin ligase complex regulating NF-κB activity and apoptosis
Nature 471, 637-641, (2011)[PubMed]

2011.3.18 高橋雅英(名大・院医・分子病理)
Miyake, H., Maeda, K., Asai, N., Shibata, R., Ichimiya, H., Isotani-Sakakibara, M., Yamamura, Y., Kato, K., Enomoto, A., Takahashi, M. and Murohara, T.
The actin-binding protein Girdin and its Akt-mediated phosphorylation regulate neointima formation after vascular injury.
Circ. Res. 108: 1170-1179 (2011)[PubMed]

2011.2.21
論文内容
武川 睦寛(名大・環境医研・分子シグナル制御)
Yuji Kubota, Pauline O’Grady, Haruo Saito and Mutsuhiro Takekawa
Oncogenic Ras abrogates MEK SUMOylation that suppresses the ERK pathway and cell transformation.
Nature Cell Biology 13, 282-291 (2011) [PubMed]
Science Signaling誌、Editors' Choice欄の対象論文に選ばれ、解説文が載りました。
科学新聞(2011年4月15日発行)

2011.2.7 徳永文稔(阪大・院医・医化学)
Kyung-Soo Inn, Michaela U. Gack, Fuminori Tokunaga, Mude Shi, Lai-Yee Wong, Kazuhiro Iwai and Jae U. Jung
Linear Ubiquitin Assembly Complex Negatively Regulates RIG-I- and TRIM25-Mediated Type I Interferon Induction
Mol Cell 41, 354-365 (2011) doi:10.1016/j.molcel.2010.12.029 [PubMed]

2011.1.28 石谷隆一郎(東大・院理・生物化学)
Hiroshi Nishimasu, Shinichi Okudaira, Kotaro Hama, Emiko Mihara, Naoshi Dohmae, Asuka Inoue, Ryuichiro Ishitani, Junichi Takagi, Junken Aoki & Osamu Nureki
Crystal structure of autotaxin and insight into GPCR activation by lipid mediators
Nature Structural & Molecular Biology (2011) doi:10.1038/nsmb.1998
[Published online 16 January 2011]

2011.1.28 高橋雅英(名大・院医・分子病理)
Matsushita, E., Asai, N., Enomoto, A., Kawamoto, Y., Kato, T., Mii, S., Maeda, K., Shibata, R., Hattori, S., Hagikura, M., Takahashi, k., Sokabe, M., Murakumo, Y., Murohara, T. and Takahashi, M.
Protective role of Gipie, a Girdin family protein, in endoplasmic reticulum stress responses in endothelial cell.
Mol. Biol. Cell. 22: 736-747 (2011). [PubMed]

2011.1.28 高橋雅英(名大・院医・分子病理)
Miyamoto, R., Jijiwa, M., Asai, M., Kawai, K., Ishida-Takagishi, M., Mii, S., Asai, N., Enomoto, A., Murakumo, Y., Yoshimura, A. and Takahashi, M.
Loss of Sprouty2 partially rescues renal hypoplasia and stomach hypoganglionosis but not intestinal aganglionosis in Ret Y1062F mutant mice.
Dev. Biol. 349: 160-168 (2011). [PubMed]

2010.11.25 市川一寿(東大医科研)
Ichikawa, K., Suzuki, T., and Murata, T.,
“Stochastic simulation of biological reactions, and its applications for studying actin polymerization”, Physical Biology, 30;7(4):046010(2010). [PubMed]

2010.11.25 市川一寿(東大医科研)
Ichikawa, K.,
“Localized activation of proteins in a free intracellular space: dependence of cellular morphologies and reaction schemes”,
BioSystems, 105(3):173-80 (2011) [PubMed]

2010.11.4 井上純一郎(東大医科研)
Motegi, H., Shimo, Y., Akiyama, T., and Inoue, J.
TRAF6 negatively regulates the Jak1-Erk pathway in interleukin-2 signaling. Genes Cells 16(2):179-89. (2010)). [PubMed]
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