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2013.4.1 池上浩司（浜松医科大学医学部　解剖学講座）
池上浩司、新間秀一、瀬藤光利
翻訳後修飾の検出と同定：チューブリンの新規翻訳後修飾の発見を例に
実験医学 「見つける、量る、可視化する！ 質量分析実験ガイド」
pp. 69-80 (2013) [URL(PDF)]
2013.2.22 山梨裕司（東大・医科研・腫瘍抑制）
Mashima R, Arimura S, Kajikawa S, Oda H, Nakae S, and Yamanashi Y.
Dok-adaptors play anti-inflammatory roles in pulmonary homeostasis.
Genes Cells, 18: 56-65 (2013) [PubMed]

Ammer AS, Soltanzadeh P, Bauche S, Richard P, Goillot E, Herbst R, Gaudon K, Huze C, Schaeffer L, Yamanashi Y, Higuchi O, Taly A, Koenig J, Leroy J, Hentati F, Najmabadi H, Kahrizi K, Ilkhani M, Fardeau M, Eymard B, and Hantai D.
A Mutation Causes MuSK Reduced Sensitivity to Agrin and Congenital Myasthenia.
PLoS One, 8: e53826 (2013) [PubMed]
2013.1.31
論文内容		 深田吉孝（東京大・院理・生化）、尾山大明（東大・医科研）
Arisa Hirano, Kanae Yumimoto, Ryosuke Tsunematsu, Masaki Matsumoto, Masaaki Oyama, Hiroko Kozuka-Hata, Tomoki Nakagawa, Darin Lanjakornsiripan, Keiichi I. Nakayama*, and Yoshitaka Fukada* (* Co-corresponding authors)
FBXL21 Regulates Oscillation of the Circadian Clock through Ubiquitination and Stabilization of Cryptochromes.
Cell, 152, 1106-1118 (2013) [PubMed]
2013.1.22 加藤順也（奈良先端科学技術大学院大学バイオサイエンス研究科）
CSN5 specifically interacts with CDK2 and controls senescence in a cytoplasmic cyclin E-mediated manner.
Yoshida A, Yoneda-Kato N, Kato JY.
Sci Rep. 2013;3:1054. doi: 10.1038/srep01054. Epub 2013 Jan 11. [URL] [PubMed]

The COP1 E3-ligase interacts with FIP200, a key regulator of mammalian autophagy.
Kobayashi S, Yoneda-Kato N, Itahara N, Yoshida A, Kato JY.
BMC Biochem. 2013 Jan 6;14(1):1. [URL] [PubMed]

Depletion of CSN5 inhibits Ras-mediated tumorigenesis by inducing premature senescence in p53-null cells.
Tsujimoto I, Yoshida A, Yoneda-Kato N, Kato JY.
FEBS Lett. 2012 Dec 14;586(24):4326-31. doi: 10.1016/j.febslet.2012.10.042. Epub 2012 Nov 2.[URL] [PubMed]
2012.12.25
論文内容		 梁 明秀（横浜市大・医・微生物学）
Nishi M, Sakai Y, Akutsu H, Nagashima Y, Quinn G, Masui S, Kimrua H, Perrem K, Umezawa A, Yamamoto N, Lee SW, Ryo A.
Induction of cells with cancer stem-cell properties from non-tumorigenic human mammary epithelial cells by defined reprogramming factors.
Oncogene, in press (2012).[PubMed]

Narita Y, Murata T, Ryo A, Kawashima D, Sugimoto A, Kanda T, Kimura H, Tsurumi T.
Pin1 interacts with the Epstein-Barr virus DNA polymerase catalytic subunit and regulates viral DNA replication.
J Virol. 2012 Dec 5. [Epub ahead of print][PubMed]

Miyakawa K, Sawasaki T, Matsunaga S, Tokarev A, Quinn G, Kimura H, Nomaguchi M, Adachi A, Yamamoto N, Guatelli J, Ryo A.
Interferon-induced SCYL2 limits release of HIV-1 by triggering PP2A-mediated dephosphorylation of the viral protein Vpu.
Science Signaling. 5(245):ra73, 2012. [PubMed] [URL]

Nakamura K, Kosugi I, Lee DY, Hafner A, Sinclair DA, Ryo A*, Lu KP*.
Prolyl isomerase Pin1 regulates neuronal differentiation via β-catenin.
Mol Cell Biol. 32:2966-2978, 2012. [PubMed]
＊Co-corres
2012.12.21
 奥村文彦（名古屋大学・理学系）
Okumura F＊, Okumura AJ, Uematsu K, Hatakeyama S, Zhang DE, Kamura T＊.
Activation of double-stranded RNA-activated protein kinase (PKR) by interferon stimulated gene 15 (ISG15) modification down-regulates protein translation.
J Biol Chem. 2012 Dec 10. [Epub ahead of print][PubMed]
＊Co-correspoinding author
2012.12.21
 高橋雅英（名大・院医・分子病理）
Ito, T., Komeima, K., Yasuma, T., Enomoto, A., Asai, N., Asai, M., Iwase, S., Takahashi, M. and Terasaki, H.
Girdin and its phosphorylation dynamically regulate neonatal vascular development and pathological neovascularization in the retina.
Am. J. Pathol. in press. [PubMed]

Asai M., Asai, N., Murata, A., Yokota, H., Ohmori, K., Mii, S., Enomoto, A., Murakumo, Y. and Takahashi, M.
Similar phenotypes of Girdin germ-line and conditional knockout mice indicate a crucial role for Girdin in the nestin lineage.
Biochem. Biophys. Res. Commun. 426: 533-538 (2012).[PubMed]
2012.11.12 浅野知一郎（広島大学　大学院医歯薬保健学研究院　医化学）
Nakatsu, Y., Otani, Y, Sakoda, H., Zhang, J., Guo, Y., Okubo, H., Kushiyama, A., Fujishiro, M., Kikuchi, T., Fukushima, T., Ohno, H., Tsuchiya, Y., Kamata, H., Nagamachi, A., Inaba, T., Nishimura, F., Katagiri, H., Takahashi, SI., Kurihara, H., Uchida, T., and Asano, T.
Role of Pin1 in the pathogenesis of non-alcoholic steatohepatitis in a rodent model.
J. Biol. Cherm. in press (2012) [PubMed] [URL]

Uchida., T., Furumai, K., Fukuda, T., Akiyama, H., Takezawa, M., Asano, T., Fujimori, F., and Uchida, C.
Prolyl isomerase Pin1 regulates mouse embryonic fibroblast differentiation into adipose cells.
PLoS One 2012;7(3):e31823[PubMed] [URL]

Nakatsu, Y., Sakoda, H., Kushiyama, A., Zhang, J., Ono, H., Fujishiro, M., Kikuchi, T., Fukushima, T., Yoneda, M., Ohno, H., Horike, N., Kanna, M., Tsuchiya, Y., Kamata, H., Nishimura, F., Isobe, T., Ogihara, T., Katagiri, H., Oka, Y., Takahashi, S., Kurihara, H., Uchida, T., and Asano, T.
Peptidyl-prolyl Cis/Trans Isomerase NIMA-interacting 1 Associates with Insulin Receptor Substrate-1 and Enhances Insulin Actions and Adipogenesis.
J. Biol. Chem. 286; 20812-22, 2011[PubMed] [URL]
2012.11.6 有賀早苗（北大・農）
Narita, R.#, Kitaura, H.#, Torii, A., Tashiro, E., Miyazawa, M., Ariga, H., Iguchi-Ariga, S.M.M. (#, These authors contributed equally to this work.) (2012).
Rabring7 degrades c-Myc through complex formation with MM-1.
PLoS ONE, 7(7):e41891.[PubMed] [URL]

Kato, I., Maita, H., Takahashi-Niki, K., Saito, Y., Noguchi, N., Iguchi-Ariga, S.M.M., and Ariga, H.
Oxidized DJ-1 inhibits p53 by sequestering p53 from promoters in a DNA-binding affinity-dependent manner
Mol. Cell. Biol., in press.[PubMed]
2012.11.6 武田弘資（長崎大学 大学院医歯薬学総合研究科　生命薬科学専攻 細胞制御学分野）
Sekine, Y., Hatanaka, R., Watanabe, T., Sono, N., Iemura, S., Natsume, T., Kuranaga, E., Miura, M., Takeda, K. and Ichijo, H.
The kelch repeat protein KLHDC10 regulates oxidative stress-induced ASK1 activation by suppressing PP5.
Mol. Cell in press [PubMed]

Hayakawa, Y., Hirata, Y., Sakitani, K., Nakagawa, H., Nakata, W., Kinoshita, H., Takahashi, R., Takeda, K., Ichijo, H., Maeda, S. and Koike, K.
Apoptosis signal-regulating kinase-1 inhibitor as a potent therapeutic drug for the treatment of gastric cancer.
Cancer Sci. in press [PubMed]
2012.11.5 石谷　太（九州大学・生体防御医学研究所）
Ishitani T and Ishitani S
Nemo-like kinase, a multifaceted cell signaling regulator
Cellular Signalling 25(1):190-197[PubMed]
2012.10.24 武川睦寛（東京大・医科研・分子シグナル制御分野）
Tomida, T., Oda, S., Takekawa, M., Iino, Y., and Saito, H.
The Temporal Pattern of Stimulation Determines the Extent and Duration of MAPK Activation in a Caenorhabditis elegans Sensory Neuron.
Science Signaling (in press) [PubMed] [URL]
2012.10.10 井上純一郎（東京大・医科研）
Yamaguchi, N., Yokota, M., Taguchi, Y., Gohda, J. and Inoue, J.
cIAP1/2 negatively regulate RANKL-induced osteoclastogenesis through the inhibition of NFATc1 expression.
Genes Cells in press (2012).[PubMed]
2012.10.10 市川一寿（東京大・医科研）
井上純一郎（東京大・医科研）
Daisuke Ohshima, Jun-ichiro Inoue, Kazuhisa Ichikawa
Roles of Spatial Parameters on the Oscillation of Nuclear NF-κB: Computer Simulations of a 3D Spherical Cell.
PLoS ONE.　7(10): e46911, 2012 [PubMed] [URL]
2012.10.5 遠藤　剛（千葉大学 大学院理学研究科 生物学教室）
Koizumi, K., Takano, K., Kanayasu, A., Watanabe-Takano, H., Tokuda, E., Abe, T., Watanabe, N., Takenawa, T., and Endo, T.
RhoD activated by fibroblast growth factor induces cytoneme-like cellular protrusions through mDia3C.
Mol. Biol. Cell 23: in press (2012) [PubMed] [URL]
2012.10.5 加納ふみ（東京大学・大学院総合文化研究科）
Kano F, Nakatsu D, Noguchi Y, Yamamoto A, Murata M (2012)
A Resealed-Cell System for Analyzing Pathogenic Intracellular Events: Perturbation of Endocytic Pathways under Diabetic Conditions.
PLoS ONE 7(8): e44127.[PubMed] [URL]
2012.9.24
論文内容		 井上純一郎（東大医科研）
Shibata, Y., Oyama, M., Kozuka-Hata, H., Han, X., Tanaka, Y., Gohda, J. and Inoue, J.
p47 negatively regulates IKK activation by inducing the lysosomal degradation of polyubiquitinated NEMO.
Nat. Commun. 3:1061 doi:10.1038/ncomms2068 (2012).[PubMed]
2012.9.24 木下英司（広島大学大学院医歯薬保健学研究院）
Eiji Kinoshita, Kinoshita-Kikuta, E., and Koike, T.
Phos-tag affinity electrophoresis for protein kinase profiling, in Protein Kinase Technologies (ed. by Mukai, H).
Neuromethods 68: Springer, New York, (2012. Jun), pp. 13–34. [Springer][PDF]

木下英司，木下恵美子，小池透
リン酸化プロテオミクスのためのPhos-tag テクノロジー
分析化学, 61: 469-487, 2012（総合論文） [J-Stage]

Kinoshita-Kikuta, E., Eiji Kinoshita, and Koike, T.
A laborsaving, timesaving, and more reliable strategy for separation of low-molecular-mass phosphoproteins in Phos-tag affinity electrophoresis.
International Journal of Chemistry, 4: 1-8, 2012 [International Journal of Chemistry]
2012.9.4 木下英司（広島大学大学院医歯薬保健学研究院）
賞の名称：日本プロテオーム学会2012年大会ポスター賞
受賞課題：改良型Phos-tag Biotinの開発とリン酸化プロテオミクスへの応用
授与年月日：2012年7月27日
受賞ポスターPDF
2012.9.4 後藤英仁（愛知がんセ・研・発がん制御）
Hidemasa Goto, Ichiro Izawa, Ping Li, and Masaki Inagaki.
Novel regulation of checkpoint kinase 1: Is checkpoint kinase 1 a good candidate for anti-cancer therapy?
Cancer Sci., 103: 1195–1200, 2012 [PubMed] [Cancer Sci]
2012.9.4 田口恵子（東北大学大学院・医学系研究科・医化学分野）
Taguchi K, Fujikawa N, Komatsu M, Ishii T, Unno M, Akaike T, Motohashi H, Yamamoto M.
Keap1 degradation by autophagy for the maintenance of redox homeostasis.
Proc Natl Acad Sci U S A. 2012 Aug 21;109(34):13561-6. [PubMed] [Yahooニュース] [プレスリリースPDF]
2012.9.4 武田弘資（長崎大学 大学院医歯薬学総合研究科　生命薬科学専攻 細胞制御学分野）
Sekine, S., Kanamaru, Y., Koike, M., Nishihara, A., Okada, M., Kinoshita, H., Kamiyama, M., Maruyama, J., Uchiyama, Y., Ishihara, N., Takeda, K. and Ichijo, H.
Rhomboid protease PARL mediates the mitochondrial membrane potential loss-induced cleavage of PGAM5.
J. Biol. Chem. 287, 34635-34645 (2012) [PubMed]

Fujisawa, T., Homma, K., Yamaguchi, N., Kadowaki, H., Tsuburaya, N., Naguro, I., Matsuzawa, A., Takeda, K., Takahashi, Y., Goto, J., Tsuji, S., Nishitoh, H. and Ichijo, H.
A novel monoclonal antibody reveals a conformational alteration shared by amyotrophic lateral sclerosis-linked SOD1 mutants.
Ann. Neurol. in press [Ann. Neurol.]

Kanamaru, Y., Sekine, S., Ichijo, H. and Takeda, K.
The phosphorylation-dependent regulation of mitochondrial proteins in stress responses. (review article)
J. Signal Transduct. 2012, 931215 (2012) [PubMed]
2012.8.13 澤崎達也（愛媛大学・無細胞生命科学工学研究センター）
Shimizu K, Takahama S, Endo Y, and Sawasaki T
Stress-inducible caspase substrate TRB3 promotes nuclear translocation of procaspase-3
PLoS ONE, 7(8): e42721, 2012 [PLoS ONE] [PubMed]

Kominami K, Nakabayashi J, Nagai T, Tsujimura Y, Chiba K, Kimura H, Miyawaki A, Sawasaki T, Yokota H, Manabe N, and Sakamaki K.
The molecular mechanism of apoptosis upon caspase-8 activation: Quantitative experimental validation of a mathematical model.
Biochim Biophys Acta. 2012 [PubMed]
2012.8.7
論文内容		 徳永文稔（群大・生調研・分子細胞制御）
石谷隆一郎（東大・院理・生物化学）
Tokunaga F.*, Nishimasu H.*, Ishitani R., Goto E., Noguchi T., Mio K., Kamei K., Ma A., Iwai K., and Nureki O. (*; equal contribution)
Specific recognition of linear polyubiquitin by A20 zinc finger 7 is involved in NF-κB regulation
EMBO J. 31, 3856-3870, (2012) [PubMed]
Science Signaling誌、上毛新聞、日本経済新聞、読売新聞などに紹介
2012.7.30 田口恵子（東北大学大学院・医学系研究科・医化学分野）
Keiko Taguchi, Nanako Fujikawa, Masaaki Komatsu, Teturo Ishii, Michiaki Unno, Takaaki Akaike, Hozumi Motohashi, and Masayuki Yamamoto
Keap1 Degradation by Autophagy for the Maintenance of Redox Homeostasis
Proc Natl Acad Sci USA, 2012 [PubMed]
2012.7.20 櫻井宏明（富山大学・院薬・がん細胞生物）
Hiroaki Sakurai
Targeting of TAK1 in inflammatory disorders and cancer.
Trends Pharmacol Sci. 2012 [PubMed]
2012.7.17 田口恵子（東北大学大学院・医学系研究科・医化学分野）
Yoichiro Mitsuishi*, Keiko Taguchi*, Yukie Kawatani, Tatsuhiro Shibata, Toshihiro Nukiwa, Hiroyuki Aburatani, Masayuki Yamamoto, Hozumi Motohashi
Nrf2 redirects glucose and glutamine into anabolic pathways in metabolic reprogramming
Cancer Cell, 22(1):66-79, 2012 [PubMed] [読売新聞] [プレスリリース詳細]
* contributed equally
2012.7.17 石谷　太（九州大学・生体防御医学研究所）
Shimizu N, Kawakami K, Ishitani T
Visualization and exploration of Tcf/Lef function using a highly responsive Wnt/β-catenin signaling-reporter transgenic zebrafish.
Developmental Biology. 2012 in press [PubMed]

Kim WT, Kim HJ, Katanaev VL, Joon Lee S, Ishitani T, Cha B, Han JK, and Jho EH
Dual functions of DP1 promote and stabilize biphasic Wnt-on and Wnt-off states during anteroposterior neural patterning
EMBO Journal. 2012 [PubMed] [EMBO J]
2012.7.9 木村洋子（東京都医学総合研究所　蛋白質代謝研究室）
Takata T, Kimura Y, Ohnuma Y, Kawawaki J, Kakiyama S, Tanaka K, Kakizuka A.
Rescue of growth defects of yeast cdc48 mutants by pathogenic IBMPFD-VCPs.
J Struct Biol. in press 2012 [PubMed]

Weiss KR, Kimura Y, Lee WC, Littleton JT.
Huntingtin aggregation kinetics and their pathological role in a Drosophila Huntington's disease model.
Genetics. 190(2):581-600 2012 [PubMed]
2012.6.13 後藤英仁（愛知がんセ・研・発がん制御）
Akihito Inoko, Makoto Matsuyama, Hidemasa Goto, Yuki Ohmuro-Matsuyama, Yuko Hayashi, Masato Enomoto, Miho Ibi, Takeshi Urano, Shigenobu Yonemura, Tohru Kiyono, Ichiro Izawa, and Masaki Inagaki.
Trichoplein and Aurora A block aberrant primary cilia assembly in proliferating cells.
J. Cell Biol. 197: 391-405, 2012. [PubMed] [J. Cell Biol.] [朝日新聞] [中日新聞] [読売新聞]
2012.6.13 有賀早苗（北大・農）
Yamaguchi, S., Yamane, T., Takahashi-Niki, K., Kato, I., Niki, T., Goldberg, M.S., Shen, J., Ishimoto, K., Doi, T., Iguchi-Ariga, S.M.M. and Ariga, H.
Transcriptional activation of low-density lipoprotein receptor gene by DJ-1 and effect of DJ-1 on cholesterol homeostasis.
PLoS ONE 7(5): e38144. (2012). [PubMed]
2012.5.30
論文内容		 高橋雅英（名大・院医・分子病理）
Ishida-Takagishi, M., Enomoto, A., Asai, N., Ushida, K., Watanabe, T., Hasimoto, T., Kato, T., Weng, L., Matsumoto, S., Asai, M., Murakumo, y., Kaibuchi, K., Kikuchi, A. and Takahashi, M.
The Dishevelled-associating protein Daple controls the non-canonical Wnt/Rac pathway and cell motility.
Nature Commun. May 29 (2012). [PubMed]

Ohara, K., Enomoto, A., Kato, T., Hashimoto, T., Isotani-Sakakibara, M., Asai, N., Ishida,-Takagishi, M., Weng, L., Nakayama, M., Watanabe, T., Kato, K., Kaibuchi, K., Murakumo, Y., Hirooka, Y., Goto, H. and Takahashi M.
Involvement of Girdin in the dermination of cell polarity during cell migration.
PLoS One, 7: e36681 (2012). [PLoS One] [PubMed]
2012.5.21 徳永文稔　(群大・生調研・分子細胞制御)
Kensche T.,* Tokunaga F.*, Ikeda F., Goto E., Iwai K., and Dikic I. (*; equal contribution)
Analysis of NF-κB essential modulator (NEMO) binding to linear and lysine-linked ubiquitin chains and its role in the activation of NF-κB.
J. Biol. Chem., 287, 23826-23834, (2012)[PubMed]

Tokunaga F. and Iwai K.
Linear ubiquitination: A novel NF-κB regulatory mechanism for inflammatory and immune responses by the LUBAC ubiquitin ligase complex.
Endocrine J., 59, 641-652, (2012)[PubMed]
2012.5.8 市川一寿（東京大・医科研）
Hoshino, D., Koshikawa, N., Suzuki, T, Quaranta, V., Weaver, A.M., Seiki, M. and Ichikawa, K.
Establishment and validation of computational model for MT1-MMP dependent ECM degradation and intervention strategies
PLoS Computational Biology. Vol.8 (2012), e1002479.[PubMed]
2012.5.8 深田吉孝（東京大・院理）
Yoshitane, H., Honma, S., Imamura, K., Nakajima, H., Nishide, S., Ono, D., Kiyota, H., Shinozaki, N., Matsuki, H., Wada, N., Doi, H., Hamada, T., Honma, I. and Fukada, Y.
JNK regulates the photic response of the mammalian circadian clock.
EMBO Reports, 13, 455-461 (2012) [PubMed]
2012.5.8 浦野友彦（東京大学抗加齢医学講座）
Takayama KI, Horie-Inoue K, Suzuki T, Urano T, Ikeda K, Fujimura T, Takahashi S, Homma Y, Ouchi Y, Inoue S.
TACC2 Is an Androgen-Responsive Cell Cycle Regulator Promoting Androgen-Mediated and Castration-Resistant Growth of Prostate Cancer.
Mol Endocrinol. 2012 Mar 28. [Epub ahead of print] [PubMed]

Urano T, Shiraki M, Yagi H, Ito M, Sasaki N, Sato M, Ouchi Y, Inoue S.
GPR98/Gpr98 Gene Is Involved in the Regulation of Human and Mouse Bone Mineral Density.
J Clin Endocrinol Metab. 2012 Apr;97(4):E565-74. Epub 2012 Mar 14. [PubMed]
2012.4.27 山岡昇司（東京医歯大・院医・ウイルス）
Adikrisna R, Tanaka S, Muramatsu S, Aihara A, Ban D, Ochiai T, Irie T, Kudo A, Nakamura N, Yamaoka S, Arii S.
Identification of Pancreatic Cancer Stem Cells and Selective Toxicity of Chemotherapeutic Agents.
Gastroenterology. 2012 Apr 14. [Epub ahead of print] [PubMed]
2012.4.25 木下英司（広島大学・医歯薬）
Eiji Kinoshita, Kinoshita-Kikuta E, Sugiyama Y, Fukada Y, Ozeki T, Koike T.
Highly sensitive detection of protein phosphorylation by using improved Phos-tag Biotin.
Proteomics. 2012 Apr;12(7):932-7. doi: 10.1002/pmic.201100639. [PubMed]

Kinoshita-Kikuta E, Eiji Kinoshita, Koike T.
Separation and identification of four distinct serine-phosphorylation states of ovalbumin by Phos-tag affinity electrophoresis.
Electrophoresis. 2012 Mar;33(5):849-55. doi: 10.1002/elps.201100518. [PubMed]

Sogame Y, Kojima K, Takeshita T, Fujiwara S, Miyata S, Eiji Kinoshita, Matsuoka T.
Protein phosphorylation in encystment-induced Colpoda cucullus: localization and identification of phosphoproteins.
FEMS Microbiol Lett. 2012 Mar 28. doi: 10.1111/j.1574-6968.2012.02560.x. [Epub ahead of print] [PubMed]
2012.4.24 沢津橋俊（群馬大学・生体調節研究所・核内情報制御）
Ito S, Fujiyama-Nakamura S, Kimura S, Lim J, Kamoshida Y, Shiozaki-Sato Y, Sawatsubashi S, Suzuki E, Tanabe M, Ueda T, Murata T, Kato H, Ohtake F, Fujiki R, Miki T, Kouzmenko A, Takeyama K, Kato S.
Epigenetic silencing of core histone genes by HERS in drosophila.
Mol Cell. 2012 Feb 24;45(4):494-504. [PubMed]
2012.4.19 有賀早苗（北大・農）
Ishikawa S, Tanaka Y, Takahashi-Niki K, Niki T, Iguchi-Ariga SMM and Ariga H.
Stimulation of vesicular monoamine transporter 2 activity by DJ-1 in SH-SY5Y cells.
Biochem. Biophys. Res. Commun. 42(4), 813-818. [PubMed]
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