Home > 研究成果 2011（平成23）年度

研究成果

2012.3.30 石谷隆一郎（東大・院理・生物化学）
Ryohei Ishii, Kazunobu Isogaya, Azusa Seto, Daizo Koinuma, Yuji Watanabe, Fumio Arisaka, So-ichi Yaguchi, Hiroaki Ikushima, Naoshi Dohmae, Kohei Miyazono, Keiji Miyazawa, Ryuichiro Ishitani and Osamu Nureki
Structure of a dominant-negative helix-loop-helix transcriptional regulator suggests mechanisms of autoinhibition
The EMBO Journal advance online publication 27 March 2012; doi:10.1038/emboj.2012.77 [EMBO] [PubMed]
2012.3.30 市川一寿（東大医科研）
Hoshino, D., Koshikawa, N., Suzuki, T, Quaranta, V., Weaver, A.M., Seiki, M. and Ichikawa, K.
Establishment and validation of computational model for MT1-MMP dependent ECM degradation and intervention strategies
PLoS Computational Biology. Vol.8 (2012), e1002479. [PubMed]
2012.3.30 池上浩司（浜松医科大学）
Konno A, Setou M, Ikegami K
Ciliary and flagellar structure and function - their regulations by posttranslational modifications of axonemal tubulin.
Int Rev Cell Mol Biol 294: 133-170, 2012[PubMed] [sciencedirect]
2012.3.1 後藤英仁（愛知がんセ・研・発がん制御）
Ping Li*, Hidemasa Goto*, Kousuke Kasahara, Makoto Matsuyama, Zhonghua Wang, Yasushi Yatabe, Tohru Kiyono and Masaki Inagaki
P90 RSK arranges Chk1 in the nucleus for monitoring of genomic integrity during cell proliferation
Mol. Biol. Cell. In Press (doi:10.1091/mbc.E11-10-0883). [PubMed]
(*These authors contributed equally.)
2012.2.27 奥村文彦（名古屋大学・理学系）
Yaguchi H, Okumura F, Takahashi H, Kano T, Kameda H, Uchigashima M, Tanaka S, Watanabe M, Sasaki H, Hatakeyama S.
TRIM67 negatively regulates Ras activity through degradation of 80K-H and induces neuritogenesis
J Biol Chem. 2012 Feb 15. [Epub ahead of print] [PubMed] [JBC]
2012.2.13 徳永文稔　(群大・生調研・分子細胞制御)
Yagi H., Ishimoto K., Hiromoto T., Fujita H., Mizushima T., Uekusa Y., Yagi-Utsumi M., Kurimoto E., Noda M., Uchiyama S., Tokunaga F., Iwai K., and Kato K.
Non-canonical UBA-UBL interaction mediates formation of linear ubiquitin chain assembly complex.
EMBO Rep., 13, 462-468 (2012) [PubMed]

Tokunaga F., and Iwai K.
LUBAC, a novel ubiquitin ligase for linear ubiquitination, is crucial for inflammation and immune responses.
Microbes Infect., in press [PubMed]

Uekusa　Y., Miura S., Sasakawa H., Kurimoto E., Sakata E., Oliver S., Yagi H., Tokunaga F., Iwai K., and Kato K.
Backbone and side chain 1H, 13C, and 15N assignments of ubiquitin-like domain of human HOIL-1L, an essential component of linear ubiquitin chain assembly complex.
Biomol. NMR Assign. in press [PubMed]
2012.2.9
論文内容		 吉田清嗣（東京医歯大・難治研・分子遺伝）
Kimura J, Kudoh T, Miki Y, and Yoshida K.
Identification of dihydropyrimidinase-related protein 4 as a novel target of the p53 tumor suppressor in the apoptotic response to DNA damage.
Int. J. Cancer 128:1524-1531 (2011) [PubMed]

Hew HC, Liu H, Miki Y, and Yoshida K.
PKCdelta regulates Mdm2 independently of p53 in the apoptotic response to DNA damage.
Mol. Carcinog. 50:719-731 (2011) [PubMed]

Hew HC, Liu H, Lu-Z-G, Kimura J, Miki Y, and Yoshida K.
Identification of Evi-1 as a novel effector of PKCdelta in the apoptotic response to DNA damage.
Biochim. Biophys. Acta 1803:285-294 (2011) [PubMed]

Taira N, Mimoto R, Kurata M, Yamaguchi T, Kitagawa M, Miki Y, and Yoshida K.
DYRK2 priming phosphorylation of c-Jun and c-Myc modulates cell cycle progression in human cancer cells.
J Clin. Invest. (2012) doi: 10.1172/JCI60818. [Epub ahead of print] [PubMed]
2012.2.6 櫻井宏明（富山大学・院薬・がん細胞生物学研究室）
Refaat A., Zhou Y., Suzuki S., Takasaki I., Koizumi K., Yamaoka S., Tabuchi Y., Saiki I., and Sakurai H.
Distinct roles of transforming growth factor-β-activated kinase 1 (TAK1)-c-Rel and interferon regulatory factor 4 (IRF4) pathways in human T cell lymphotropic virus 1-transformed T helper 17 cells producing interleukin-9.
J. Biol. Chem. 286: 21092-21099, 2011. [PubMed]

Mizumoto Y., Kyo S., Kiyono T., Takakura M., Nakamura M., Maida Y., Mori N., Bono Y., Sakurai H., and Inoue M.
Activation of NF-κB is a novel target of KRAS-induced endometrial carcinogenesis.
Clin. Cancer Res. 17: 1341-1350, 2011. [PubMed]

Waiwut P., Shin M.S., Inujima A., Zhou Y., Koizumi K., Saiki I., and Sakurai H.
Gomisin N enhances TNF-α-induced apoptosis via inhibition of NF-κB and EGFR survival pathways.
Mol. Cell. Biochem., 350: 169-175, 2011. [PubMed]
2012.2.3 清宮啓之（がん研・がん化療セ・分子生物治療）
Miyazaki T, Pan Y, Joshi K, Purohit D, Hu B, Demir H, Mazumder S, Okabe S, Yamori T, Viapiano MS, Shin-Ya K, Seimiya H, Nakano I.
Telomestatin impairs glioma stem cell survival and growth through the disruption of telomeric G-quadruplex and inhibition of the proto-oncogene, c-Myb.
Clin Cancer Res., in press. [PubMed]

Ha GH, Kim HS, Go H, Lee H, Seimiya H, Chung DH, Lee CW.
Tankyrase-1 function at telomeres and during mitosis is regulated by Polo-like kinase-1-mediated phosphorylation.
Cell Death Differ. 19: 321-32 (2012) [PubMed]
2012.2.3 加納ふみ（東京大学・大学院総合文化研究科）
Taichi Sugawara, Daiki Nakatsu, Hiroaki Kii, Nobuhiko Maiya, Atsuhiro Adachi, Akitsugu Yamamoto, Fumi Kano, Masayuki Murata.
PKCδ and ε regulate the morphological integrity of the ER-Golgi intermediate compartment (ERGIC) but not the anterograde and retrograde transports via the Golgi apparatus.
Biochim Biophys Acta.(Molecular Cell Research)1823(4):861-875.[PubMed] [URL]
2012.2.3 武田弘資（東京大学・院薬・細胞情報）
Nakagawa, H., Hirata, Y., Takeda, K., Hayakawa, Y., Sato, T., Kinoshita, H., Sakamoto, K., Nakata, W., Hikiba, Y., Omata, M., Yoshida, H., Koike, K. Ichijo, H. and Maeda, S.
Apoptosis signal-regulating kinase 1 inhibits hepatocarcinogenesis by controlling the tumor-suppressing function of stress-activated MAPK.
Hepatology 54, 185-195 (2011) [PubMed]

Sekine,Y., Takagahara,S., Hatanaka, R., Watanabe, T., Oguchi, H., Noguchi, T., Naguro, I., Kobayashi, K., Tsunoda, M., Funatsu, T., Nomura, H., Toyoda, T., Matsuki, N., Kuranaga, E., Miura, M., Takeda, K. and Ichijo,H.
p38 MAP kinase regulates the expression of genes in the dopamine synthesis pathway through phosphorylation of NR4A nuclear receptors.
J. Cell Sci. 124, 3006-3016 (2011) [PubMed]

Takeda, K., Naguro, I., Nishitoh, H., Matsuzawa, A. and Ichijo, H.
Apoptosis signaling kinases: from stress response to health outcomes. (Review article)
Antioxid. Redox Signal. 15, 719-761 (2011) [PubMed]
2012.2.3 石戸聡（理化学研究所 免疫・アレルギー科学総合研究センター）
Baravalle, G., Park, H., McSweeney, M., Ohmura-Hoshino, M., Matsuki, Y., Ishido, S. and Shin, JS*.
Ubiquitination of CD86 Is a Key Mechanism in Regulating Antigen Presentation by Dendritic Cells.
J. Immunol. 2011 Sep 15;187(6):2966-73. Epub 2011 Aug 17. [PubMed]

Hidetaka Tanno, Teppei Yamaguchi, Eiji Goto, Satoshi Ishido, and Masayuki Komada
The Ankrd 13 family of UIM-bearing proteins regulates EGF receptor endocytosis from the plasma membrane
Mol. Biol. Cell 2012 mbc.E11-09-0817; First Published on February 1, 2012; doi:10.1091/mbc.E11-09-0817 [PubMed]
2012.2.3 山梨裕司（東京大学・医科研・腫瘍抑制分野）
Johko Hamuro, Yukihiro Hishida, Osamu Higuchi, and Yuji Yamanashi.
The transcription factor Sp1 plays a crucial role in dok-7 gene expression.
Biochem. Biophys. Res. Commun., 408: 293-299 (2011) [PubMed]

Aya Kawamata, Akane Inoue, Daisuke Miyajima, Hiroaki Hemmi, Ryuichi Mashima, Tadayoshi Hayata, Yoichi Ezura, Teruo Amagasa, Yuji Yamanashi*, and Masaki Noda*. (*corresponding authors)
Dok-1 and Dok-2 deficiency induces osteopenia via regulation of osteoclasts.
J. Cell. Physiol. 226: 3087-3093 (2011) [PubMed]
2012.2.3 西 英一郎（京都大学・院医・循環器内科学）
Kanda K, Komekado H, Sawabu T, Ishizu S, Nakanishi Y, Nakatsuji M, Akitake-Kawano R, Ohno M, Hiraoka Y, Kawada M, Kawada K, Sakai Y, Matsumoto K, Kunichika M, Kimura T, Seno H*, Nishi E*, and ChibaT (*Co-corresponding author)
Nardilysin and ADAM proteases promote gastric cancer cell growth by activating intrinsic cytokine signaling via enhanced ectodomain shedding of TNF-α
EMBO Mol Med, 2012 Feb 20. doi: 10.1002/emmm.201200216. [PubMed]

Li J, Chu M, Wang S, Chan D, Qi S, Wu M, Zhou Z, Li Z, Nishi E, Qin J and Wong J
Identification and Characterization of Nardilysin as a Novel Dimethyl H3K4 Binding Protein Involved in Transcriptional Regulation
J Biol Chem, 2012 in press [PubMed]
2012.2.3 梁　明秀（横浜市立大学・院医・微生物学）
Nishi M, Akutsu H, Masui S, Kondo A, Nagashima Y, Kimura H, Perrem K, Shigeri Y, Toyoda M, Okayama A, Hirano H, Umezawa A, Yamamoto N, Lee SW, Ryo A.
A distinct role for Pin1 in the induction and maintenance of pluripotency.
J Biol Chem. 2011 Apr 1;286(13):11593-603. Epub 2011 Feb 4. [PubMed]

Endoh K, Nishi M, Ishiguro H, Uemura H, Miyagi Y, Aoki I, Hirano H, Kubota Y, Ryo A.
Identification of phosphorylated proteins involved in the oncogenesis of prostate cancer via Pin1-proteomic analysis.
Prostate. 2011 Aug 1. doi: 10.1002/pros.21466. [Epub ahead of print] [PubMed]
2012.2.3 井上純一郎（東大医科研）
Mouri, Y., Yano, M., Shinzawa, M., Shimo, Y., Hirota, F., Nishikawa, Y., Nii, T., Kiyonari, H., Abe, T., Uehara, H., Izumi, K., Tamada, K., Chen, L., Penninger, J. M., Inoue, J., Akiyama, T., and Matsumoto, M.
Lymphotoxin Signal Promotes Thymic Organogenesis by Eliciting RANK Expression in the Embryonic Thymic Stroma.
J. Immunol. 186, 5047-5057 (2011). [PubMed]

Ohno, T., Oboki, K., Kajiwara, N., Tanaka, S., Ikeda, M., Iikura, M., Akiyama, T., Inoue, J., Matsumoto, K., Sudo, K., Azuma, M., Okumura, K., Kamradt, T., Saito, H., and Nakae, S.
Paracrine IL-33 stimulation enhances lipopolysaccharide-mediated macrophage activation.
PLoS ONE 6(4):e18404 (2011). [PubMed]

Shibata, Y., Tanaka, Y., Gohda, J., and Inoue, J.
Activation of the IκB kinase complex by HTLV-1 Tax requires cytosolic factors involved in Tax-induced polyubiquitination.
J. Biochem. 150, 679-686 (2011). [PubMed]

Kanemaru, Y., Momiki, Y., Matsuura, S., Horikawa, T., Gohda, J., Inoue, J., Okamoto, Y., Fujita, F., and Otsuka M.
An artificial copper complex incorporating a cell-penetrating peptide inhibits NF-κB activation.
Chem. Pharm. Bull. 59, 1555-1558 (2011). [PubMed]

Shinzawa, M., Maruyama, T., Qin, J., Akiyama, N., Miyauchi, M., Yanai H., Takami, M., Inoue, J., and Akiyama, T.
Splenic extramedullary hemopoiesis caused by a dysfunctional mutation in the NF-κB inducing kinase gene
Biochem. Biophys. Res. Commun. 414, 773-778 (2011). [PubMed]

Ohba, T., Ariga, Y., Maruyama, T., Truong, N., Inoue, J., and Muta, T.
Identification of interleukin-1 receptor-associated kinase 1 as a critical component that induces post-transcriptional activation of IκB-ζ.
FEBS J. 279, 211-222 (2011). [PubMed]
2012.2.3 越川直彦（東京大学医科研・腫瘍細胞社会学分野）
Saitou T, Rouzimaimaiti M, Koshikawa N, Seiki M, Ichikawa K, Suzuki T.
Mathematical modeling of invadopodia formation.
J Theor Biol. 2011 Dec 29;298C:138-146. [Epub ahead of print] [PubMed]

Hamasaki H, Koga K, Aoki M, Hamasaki M, Koshikawa N, Seiki M, Iwasaki H, Nakayama J, Nabeshima K.
Expression of laminin 5-γ2 chain in cutaneous squamous cell carcinoma and its role in tumour invasion.
Br J Cancer. 2011 Sep 6;105(6):824-32. doi: 10.1038/bjc.2011.283. Epub 2011 Aug 9. [PubMed]

Nagano M, Hoshino D, Koshiba S, Shuo T, Koshikawa N, Tomizawa T, Hayashi F, Tochio N, Harada T, Akizawa T, Watanabe S, Handa N, Shirouzu M, Kigawa T, Yokoyama S, Seiki M.
ZF21 protein, a regulator of the disassembly of focal adhesions and cancer metastasis, contains a novel noncanonical pleckstrin homology domain.
J Biol Chem. 2011 Sep 9;286(36):31598-609. Epub 2011 Jul 15. [PubMed]
2012.2.3 奥村文彦（名古屋大学・理学系）
Okumura F*, Matsuzaki M, Nakatsukasa K, Kamura T* (*Co-corresponding author)
The Role of Elongin BC-containing ubiquitin ligases
Frontiers in Molecular and Cellular Oncology [PubMed] [URL]

Sato T, Okumura F, Iguchi A, Ariga T, Hatakeyama S.
TRIM32 promotes retinoic acid receptor α-mediated differentiation in human promyelogenous leukemic cell line HL60.
Biochem. Biophys. Res. Commun. 2012 Jan 6;417(1):594-600. Epub 2011 Dec 11. [PubMed]
2012.2.3 木下英司（広島大学・院医歯薬学総合・医薬分子機能）
Somura, M., Takiyama, K., Kinoshita-Kikuta, E., Eiji Kinoshita, and Koike T.
A Phos-tag-based fluorescence resonance energy transfer system for the analysis of the kinase reaction of a substrate peptide.
Anal. Methods, 3: 1303-1309., 2011 [PubMed] [URL]

Sogame, Y., Eiji Kinoshita, and Matsuoka, T.
Ca2+-dependent in vivo protein phosphorylation and encystment induction in the ciliated protozoan Colpoda cucullus.
Eur. J. Protistol. 47: 208-213., 2011 [PubMed]

Sogame, Y., Asami, H., Eiji Kinoshita, and Matsuoka, T.
Possible involvement of cAMP and protein phosphorylation in the cell signaling pathway for resting cyst formation of ciliated protozoan Colpoda cucullus.
Acta Protozool. 50: 71-79., 2011 [PubMed][URL]
2012.2.3 伊村明浩（先端医療センター・医薬品開発研究グループ）
Asai O, Nakatani K, Tanaka T, Sakan H, Imura A, Yoshimoto S, Samejima KI, Yamaguchi Y, Matsui M, Akai Y, Konishi N, Iwano M, Nabeshima Y, Saito
Decreased renal α-Klotho expression in early diabetic nephropathy in humans and mice and its possible role in urinary calcium excretion.
Kidney Int. 2012 Jan 4. [PubMed]

Ohata Y, Arahori H, Namba N, Kitaoka T, Hirai H, Wada K, Nakayama M, Michigami T, Imura A, Nabeshima Y, Yamazaki Y, Ozono K.
Circulating levels of soluble alpha-Klotho are markedly elevated in human umbilical cord blood.
J Clin Endocrinol Metab. 2011 Jun;96(6):E943-7. [PubMed]
2012.1.31
論文内容		 石谷　太（九州大学・生体防御医学研究所）
Ota S, Ishitani S, Shimizu N, Matsumoto K, Itoh M, Ishitani T
NLK positively regulates Wnt/beta-catenin signalling by phosphorylating LEF1 in neural progenitor cells
EMBO Journal, 2012 Feb 28. doi: 10.1038/emboj.2012.46. [PubMed]
2012.1.27 池上浩司（浜松医科大学）
Lee JE, Silhavy JL, Zaki MS, Schroth J, Bielas SL, Marsh SE, Olvera J, Brancati F, Iannicelli M, Ikegami K, Schlossman AM, Merriman B, Attié-Bitach T, Logan CV, Glass IA, Cluckey A, Louie CM, Lee JH, Raynes HR, Rapin I, Castroviejo IP, Setou M, Barbot C, Boltshauser E, Nelson SF, Hildebrandt F, Johnson CA, Doherty DA, Valente EM, Gleeson JG.
CEP41 is mutated in Joubert syndrome and is required for tubulin glutamylation at the cilium.
Nat Genet, doi: 10.1038/ng.1078., 2012 [PubMed] [Nat. Genet]
2012.1.6 櫻井宏明（富山大学・院薬・がん細胞生物）
Wolf A., Beuerlein K., Eckart C., Weiser H., Dickkopf B., Müller H., Sakurai H., and Kracht M
Identification and functional characterization of a novel phosphorylation sites in TAK1-binding protein (TAB) 1.
PLoS ONE, 6: e29256, 2011. [PubMed]
2012.1.6 浦野友彦（東京大学抗加齢医学講座）
Endo H, Ikeda K, Urano T, Horie-Inoue K, Inoue S.
Terf/TRIM17 stimulates degradation of kinetochore protein ZWINT and regulates cell proliferation.
J Biochem. 2011 Oct 24. [Epub ahead of print] [PubMed]
2011.12.20 武田弘資（東京大・院薬・細胞情報学）
Ishida Y, Sekine Y, Oguchi H, Chihara T, Miura M, Ichijo H, Takeda K
Prevention of apoptosis by mitochondrial phosphatase PGAM5 in the mushroom body is crucial for heat shock resistance in Drosophila melanogaster.
PLoS ONE, 2012;7(2):e30265. Epub 2012 Feb 7. [PubMed]
2011.12.20 池上浩司（浜松医科大学）
Berezniuk I, Vu HT, Lyons PJ, Sironi JJ, Xiao H, Burd B, Setou M, Angeletti RH, Ikegami K, Fricker LD
Cytosolic carboxypeptidase 1 is involved in processing of alpha-tubulin and beta-tubulin.
J Biol. Chem. 2011[JBC] [PubMed]
2011.12.5
論文内容		 木下英司（広島大学・医歯薬）
Eiji Kinoshita, Emiko Kinoshita-Kikuta, and Tohru Koike
Phos-tag SDS-PAGE systems for phosphorylation profiling of proteins with a wide range of molecular masses under neutral pH conditions.
Proteomics, 11: 319-323, 2011 [PubMed] [Cover pictureに採用されました]
2011.12.5 木下英司（広島大学・医歯薬）
賞の名称：日本電気泳動学会児玉賞（第50回）
受賞者：木下英司（広島大学大学院医歯薬学総合研究科）
受賞課題：Phos-tag親和電気泳動法の開発
授与年月日：2011年11月12日
2011.11.25
論文内容		 佐藤裕介（東大・構造生物）
Yusuke Sato, Hiroaki Fujita, Azusa Yoshikawa, Masami Yamashita, Atsushi Yamagata, Stephen E. Kaiser, Kazuhiro Iwai, Shuya Fukai
Specific recognition of linear ubiquitin chains by the Npl4 zinc finger (NZF) domain of the HOIL-1L subunit of the linear ubiquitin chain assembly complex
PNAS. 2011 Dec 20;108(51):20520-5. Epub 2011 Dec 2. [PubMed]
2011.11.10 山岡昇司（東京医歯大・院医・ウイルス）
Uota S, Dewan MZ, Saitoh Y, Muto S, Itai A, Utsunomiya A, Watanabe T, Yamamoto N, Yamaoka S.
An IκB kinase 2 inhibitor IMD-0354 suppresses the survival of adult T-cell leukemia cells.
Cancer Sci. 2011 Sep 23. doi: 10.1111/j.1349-7006.2011.02110.x. [Epub ahead of print] [PubMed]
2011.11.10 山岡昇司（東京医歯大・院医・ウイルス）
Kondo S, Wakisaka N, Muramatsu M, Zen Y, Endo K, Murono S, Sugimoto H, Yamaoka S, Pagano JS, Yoshizaki T.
Epstein-barr virus latent membrane protein 1 induces cancer stem/progenitor-like cells in nasopharyngeal epithelial cell lines.
J Virol. 2011 Nov;85(21):11255-64. Epub 2011 Aug 17. [PubMed]
2011.11.10 奥村文彦（名大・理）
Noguchi K, Okumura F, Takahashi N, Kataoka A, Kamiyama T, Todo S, Hatakeyama S.
TRIM40 promotes neddylation of IKKγ and is downregulated in gastrointestinal cancers.
Carcinogenesis. 2011 Jul;32(7):995-1004. Epub 2011 Apr 7. [PubMed]
2011.11.11 奥村文彦（名大・理）
Sato T, Okumura F, Kano S, Kondo T, Ariga T, Hatakeyama S.
TRIM32 promotes neural differentiation through retinoic acid receptor-mediated transcription.
J Cell Sci. 2011 Oct 15;124(Pt 20):3492-502. Epub 2011 Oct 7.[PubMed]
2011.11.11 奥村文彦（名大・理）
Sato, T., Okumura, F., Ariga, T. and Hatakeyama, S
TRIM6 interacts with c-Myc and maintains pluripotency of mouse embryonal stem cells.
J. Cell Sci., (2012) [PubMed]
2011.11.4 徳永文稔（群大・生調研・分子細胞制御）
Tomonaga M, Hashimoto N, Tokunaga F, Onishi M, Myoui A, Yoshikawa H, and Iwai K.; Activation of nuclear factor-kappaB by linear ubiquitin chain assembly complex contributes to lung metastasis of osteosarcoma.
Int. J. Oncl. 40: 409-417, (2012) [PubMed]
2011.10.26 池上浩司（浜松医科大学）
Asakawa H, Ikegami K, Setou M, Watanabe N, Tsukada M, Fukuma T
Submolecular-scale imaging of α-helices and C-terminal domains of tubulins by frequency modulation atomic force microscopy in liquid.
Biophys. J. 101: 1270-1276 (2011) [PubMed]
2011.10.26 越川直彦（東大・医科研）
Takayuki Uematsu, Chieko Konishi, Daisuke Hoshino, Xiao Han, TaizoTomari, Nagayasu Egawa, Yoshikazu Takada, Toshiaki Isobe, Professor Motoharu Seiki and Naohiko Koshikawa
Identification of proteins that associate with integrin α2 by proteomic analysis in human fibrosarcoma HT-1080 cells
J Cell Physiol. 2011 Oct 11. doi: 10.1002/jcp.23054 [PubMed]
2011.9.25 高橋雅英（名大・院医・分子病理）
Kato T, Kinjo S, Natsume A, Enomoto A, Toda H, Shimoato S, Ohka F, Motomura K, Kondo Y, Miyata T, Takahashi M and Wakabayashi, T.
Girdin maintains the stemness of glioblastoma stem cells.
Oncogene in press. [PubMed]
2011.9.21 武川睦寛（名大・環境医研・分子シグナル制御）
Otsuka M, Takata A, Yoshikawa T, Kojima K, Kishikawa T, Shibata C, Takekawa M, Yoshida H, Omata M, and Koike K.
Receptor for Activated Protein Kinase C: Requirement for Efficient MicroRNA Function and Reduced Expression in Hepatocellular Carcinoma.
PLoS ONE 6: e24359, 2011 [Plos ONE]
2011.7.5 有賀早苗（北大・農）
Kitamura Y, Watanabe　S, Taguchi M, Takagi K, Kawata T, Takahashi-Niki K, Yasui H, Maita H, Iguchi-Ariga SMM and Ariga H.
Neuroprotective effect of a new DJ-1-binding compound against neurodegeneration in Parkinson's disease and stroke model rats.
Molecular Neurodegeneration. Jul 8;6(1):48, 2011 [PubMed]
2011.6.30 奥村文彦（名大・理）
Okumura F, Okumura AJ, Matsumoto M, Nakayama KI, Hatakeyama S.
TRIM8 regulates Nanog via Hsp90β-medicated nuclear translocation of STAT3 in embryonic stem cells.
Biochim Biophys Acta. 2011 Jun 2. [Epub ahead of print] [PubMed]
2011.6.30 奥村文彦（名大・理）
Okumura F, Yoshida K, Liang F, Hatakeyama S.
MDA-9/syntenin interacts with ubiquitin via a novel ubiquitin-binding motif.
Mol Cell Biochem. 2011 Jun;352(1-2):163-72. Epub 2011 Feb 27. [PubMed]
2011.6.20 後藤英仁（愛知がんセ・研・発がん制御）
*Matsuyama M., *Goto H., *Kasahara K., Kawakami Y., Nakanishi M., Kiyono T., Goshima N., and Inagaki M.
Nuclear Chk1 prevents premature mitotic entry.
J. Cell Sci. 124: 2113-2119, 2011. [PubMed]
(*These authors contributed equally.)
2011.6.17 井上純一郎（東大医科研）
Ohshima, D., Qin, J., Konno, H., Hirosawa, A., Shiraishi, T., Yanai, H., Shimo, Y., Shinzawa, M., Akiyama, N., Yamashita, R., Nakai, K., Akiyama, T, and Inoue, J.
RANK signaling induces interferon-stimulated genes in the fetal thymic stroma
Biochem. Biophys. Res. Commun. 408, 530-536 (2011) [PubMed]
2011.5.17
論文内容		 高橋雅英（名大・院医・分子病理）
Wang, Y., Kaneko, N., Asai, N., Enomoto, A., Isotani-Sakakibara, M., Kato, T., Asai, M., Murakumo, Y., Ota, H., Hikita, T., Namba, T., Kuroda, K., Kaibuchi, K., Ming, G., Song, H., Sawamoto, K. and Takahashi, M.
Girdin is an intrinsic regulator of neuroblast chain migration in the rostral migratory stream of the postnatal brain.
J. Neurosci. 31: 8109-8122 (2011). [PubMed]
2011年度　2010年度